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Soldevilla
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a 2'-O-tert-butyldimethylsilyl (TBDMS) protecting group for 2'-hydroxyl protection
} DMT-2'-O-Me-A(Bz)-CE Phosphoramidite is a 2'-OMe phosphoramidite monomer used for solid-phase oligonucleotide synthesis
} DMT-2’-F-dU-CE-Phosphoramidite is a 2'-fluoro (2'-F) phosphoramidite monomer used for solid-phase oligonucleotide synthesis
1-N-Me-Pseudo UTP, 200mM Tris Salt Solution RNA (2'-O-TBDMS) Phosphoramidites SoldevillaN1 methyl pseudouridine 5 triphosphate (m1TP) is a chemically modified uridine nucleotide designed for enzymatic incorporation into RNA during IVT using RNA polymerases such as T7 RNA polymerase. m1TP is an N1 methylated derivative of pseudouridine that preserves base pairing properties while altering innate immune recognition. When substituted for uridine in IVT, m1 reduces activation of innate immune sensors and enhances translational efficiency of